Controlled study
Sleep extension and energy intake: the Tasali trial
In Tasali's trial involving 80 adults with overweight and short sleep, two weeks of sleep extension produced a −270 kcal/day difference in the change in estimated energy intake relative to control (95% CI −393 to −147).
In the same trial, the difference in sleep duration was 1.2 hours per night in favor of the intervention (95% CI 1.0–1.4).
Weight results during 68 or 72 treatment weeks and a two-week sleep intervention answer different questions from a withdrawal comparison after initial treatment. SURMOUNT-4 provides that specific comparison for 52 weeks after randomization.
- Evidence design
- Randomized parallel clinical trial
- Population
- Adults aged 21–40 years, with BMI 25.0–29.9 kg/m² and habitual sleep shorter than 6.5 h/night.
- Assessment period
- Two intervention weeks following two baseline weeks
- Reported units
- kcal/day; hours/night
Keep in view
- 80 adults aged 21–40 with overweight and habitual sleep shorter than 6.5 hours; single center.
- Two intervention weeks do not establish sustained weight-loss maintenance.
- Intake was estimated from energy balance, not measured by directly counting food.
See study details — Sleep extension trial
Study design and methods
Randomized parallel clinical trial
Single-center randomized trial; two baseline weeks and two intervention weeks in the usual environment; intention-to-treat analysis.
Population
Adults aged 21–40 years, with BMI 25.0–29.9 kg/m² and habitual sleep shorter than 6.5 h/night.
- Study design
- Single-center randomized trial; two baseline weeks and two intervention weeks in the usual environment; intention-to-treat analysis.
- Reported sample count
- 80
- Role of the reported sample count
- Reported study sample; not necessarily the denominator for each outcome
- Included study count
- 1
- Role of the study count
- Single study
- Research question
- Does extending sleep reduce objectively estimated energy intake in adults with overweight and short sleep?
- Qualified findings
- Counseling to extend sleep increased sleep duration and reduced estimated intake compared with control. Total expenditure did not differ significantly. This is a two-week finding; it does not demonstrate weight-loss maintenance.
- Estimand and analysis rules
- Not reported or not verified
- Reason the formal estimand is unavailable
- A complete formal estimand was not extracted from the verified input.
Extracted outcomes
| Outcome and group | Reported value | Assessment period | Sample and denominators | Uncertainty |
|---|---|---|---|---|
| Sleep duration Sleep extension minus control Effect estimate | 1.2 hours/night reported between-group change difference Unit: hours/night | Two intervention weeks following two baseline weeks | Reported N: 80 — total randomized trial sample; not a group denominator
| 95% confidence interval: 1 to 1.4 Reported p-value: <0.001 (Between-group comparison) |
| Estimated energy intake Sleep extension minus control Effect estimate | -270 kcal/day reported between-group change difference Unit: kcal/day | Two intervention weeks following two baseline weeks | Reported N: 80 — total randomized trial sample; not a group denominator
| 95% confidence interval: -393 to -147 Reported p-value: <0.001 (Between-group comparison) |
Sleep duration — Sleep extension minus control: extraction context
- Outcome role
- Not specified in the consulted scope
- Scale reference
- intervention_vs_control_change
- Estimand and analysis rules
- Name
- Not reported or not verified
- Analysis population
- Intention-to-treat, as described in the verified input
- formal estimand not extracted
- Yes
- Extraction location
- Original article abstract; intervention duration checked in PMC full text
- N=80 is the trial total; arm sizes and effect-specific N were not extracted.
Estimated energy intake — Sleep extension minus control: extraction context
- Outcome role
- Not specified in the consulted scope
- Scale reference
- intervention_vs_control_change
- Estimand and analysis rules
- Name
- Not reported or not verified
- Analysis population
- Intention-to-treat, as described in the verified input
- formal estimand not extracted
- Yes
- Extraction location
- Original article abstract; intervention duration checked in PMC full text
- N=80 is the trial total; arm sizes and effect-specific N were not extracted.
What the curated evidence supports
- In Tasali's trial involving 80 adults with overweight and short sleep, two weeks of sleep extension produced a −270 kcal/day difference in the change in estimated energy intake relative to control (95% CI −393 to −147).
- In the same trial, the difference in sleep duration was 1.2 hours per night in favor of the intervention (95% CI 1.0–1.4).
- Weight results during 68 or 72 treatment weeks and a two-week sleep intervention answer different questions from a withdrawal comparison after initial treatment. SURMOUNT-4 provides that specific comparison for 52 weeks after randomization.
Limitations
- 80 adults aged 21–40 with overweight and habitual sleep shorter than 6.5 hours; single center.
- Two intervention weeks do not establish sustained weight-loss maintenance.
- Intake was estimated from energy balance, not measured by directly counting food.
Verification scope
Verified through 2026-11-04 within the consulted scope.
- Bibliographic metadata checked
- Yes
- Original article abstract consulted
- Yes
- Full-text consultation
- selected_fields_only
- full text verified fields
- intervention_duration
- pmcid_linkage
- Official trial registry consulted
- No
- Statistical analysis plan consulted
- No
- Verification boundary
- Verification is limited to the input's identified abstract/full-text fields. A trial identifier linked by an article does not imply a separate registry review.
Source record
Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial (2022)
Source identifiers
- PubMed record 35129580
- PubMed Central: PMC8822469
- Article DOI: 10.1001/jamainternmed.2021.8098