Understand trial averages, head-to-head comparisons, estimands, denominator differences, and why body-composition and safety findings need their own context.
Separate short sleep experiments, energy-intake estimates, and acute stress findings without claiming a universal hormonal mechanism or long-term weight effect.
Understand the selected SURMOUNT-4 withdrawal comparison, its lead-in selection, week-of-randomization reference weight, and the limits of translating trial follow-up into an individual plan.
Publication and editorial-review dates describe preparation of these articles, not a new scientific reappraisal. The scientific source verification remains limited to the canonical release verified through 2026-11-04. This is a directed evidence selection, not a systematic review or GRADE assessment.